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Interstate 44 (I-44) is a major Interstate Highway in the central United States. Although it is nominally an east-west road as it is even-numbered, it follows a more southwest-northeast alignment. Its western terminus is in Wichita Falls, Texas at a concurrency with U.S. Route 277 (US 277), US 281, and U.S. Route 287 in Texas; its eastern terminus is at I-70 in St. Louis, Missouri.
I-44 is one of five interstates built to bypass U.S. Route 66; this highway covers the section between Oklahoma City and St. Louis.